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By proceeding to the Mydiavac Vaccine Guide you agree that you are one of the following

Professional Keeper of animals, Veterinary surgeon, Veterinary nurse, Veterinary student, Pharmacist or SQP

Mydiavac - Proven enzootic abortion protection,
flexible and practical administration

INTRODUCTION

Abortion is a significant animal welfare, human health and economic threat to the sheep industry. It is widespread globally and, whilst some cases are caused by poor management or nutritional factors, infectious agents are responsible for much of the problem.

Enzootic Abortion of Ewes (EAE) is the most prevalent cause of abortion in the UK sheep flock, responsible for around 50% of abortion cases (EBLEX, 2012). EAE is caused by the bacterium Chlamydophila abortus, and is therefore also known as chlamydial abortion.

EAE is characterised by late term abortions, stillbirths and weak lambs, and also by an inflamed, reddish brown placenta. The disease is transmitted by ingestion following exposure to infected foetal membranes and lambing discharges. Infection does not result in abortion in that pregnancy unless the ewe is less than 14 weeks pregnant. Instead, the infection remains latent in the ewe until the next pregnancy when it causes abortion.

EFFICACY

Mydiavac® provides proven protection for naïve breeding ewes against Enzootic abortion (Chlamydophila abortus) infection when administered before tupping.

If a pre-tupping dose has not been administered — either due to due to lack of time or purchasing animals with unknown vaccine status — Mydiavac® can be used at any stage of pregnancy.

If you unfortunately encounter an EAE outbreak in your flock, Mydiavac® administration in the face of an outbreak has been proven to reduce the level of abortion in infected pregnant ewes. If a high population of ewes are naive when their flock-mates are aborting, Mydiavac administration in the face of an outbreak can also reduce the number becoming latently infected and result in fewer EAE abortions the following year.

Mydiavac - Proven enzootic abortion protection,
flexible and practical administration


Mydiavac - Proven enzootic abortion protection,
flexible and practical administration


FLEXIBILITY -
THE MYDIAVAC® CYCLE

Pre-tupping vaccination with Mydiavac® is considered best practice, but because it is an inactivated vaccine it may also be administered at many other stages of the sheep calendar:

  • - Winter or Spring: when EAE first strikes in the flock pre-lambing, to achieve quick protection for non EAE exposed ewes.
  • - Spring or Summer: when gathering ewes and lambs to minimise handling and labour requirements.
  • - Summer: when ewe replacements chosen or purchased.
  • - Summer or Autumn: with a live toxoplasmosis vaccine.
  • - Autumn: up to 3-4 weeks pre-tupping.
  • - Autumn or Winter: after removal of the tup.
  • - Winter: following scanning of ewes.

PRACTICALITY

  • - 1ml dose for ease of storage and administration.
  • - 100 dose (100ml) or 20 dose (20ml) packs to minimise waste.
  • - Once broached the contents of the vial may be used for the whole working day.
  • - Sealed 100ml Mydiavac® vials have a 14 month shelf life, and 20ml vials have 12 months.
  • - Mydiavac® is provided ready to use: no mixing with solvents required.
  • - Mydiavac® can be given at the same time as a commercial Toxoplasma gondii vaccine containing live tachyzoites of the S48 strain, providing different syringes and injection sites are used.
Mydiavac - Proven enzootic abortion protection,
flexible and practical administration


Benchmark Animal Health

We are a UK based company with a unique "3E's" approach to sustainable business development, where equal value is placed on ethics, environment and economics. By focusing our extensive research and development plans solely on improving animal health and welfare, we are committed to a healthy and prosperous UK livestock farming community. The reintroduction of this unique inactivated Enzootic abortion vaccine offers farmers a highly flexible and practical administration process and increased control options in the face of an EAE outbreak.

Benchmark Animal Health has moved rapidly to reintroduce Mydiavac® to the UK sheep sector and fortunately, owing to the excellent cooperation from the regulators, we hope to make some product available for 2014 pre-tupping vaccination, with full supply in place by Winter 2014. We are committed to helping those flocks unfortunate to encounter EAE around lambing and farmers who wish to vaccinate their stock in 2015 and beyond. Please speak to your vet should you encounter any abortion problems during your next lambing season and discuss whether Mydiavac® is appropriate for your flock.

MYDIAVAC®

EAE VACCINE / USAGE INSTRUCTIONS

PRESENTATION. A white emulsion of water in oil containing 2 x 108eb inactivated Chlamydophila abortus per dose, preserved with thiomersal 0.013% w/v.

USES. For the active immunisation of susceptible breeding female sheep against Chlamydophila abortus infection as an aid in the prevention of abortion caused by this organism. Studies to date indicate that the protection afforded should exist for at least 771 days post initial vaccination.

DOSAGE & ADMINISTRATION. Dose-1ml to be administered intramuscularly. The recommended injection site is a point 3”-4” in front of the shoulder in the middle of the neck.

Primary vaccination: Sheep should receive 1 dose of vaccine. Animals should be vaccinated approximately 1 month prior to mating or from 4 weeks after the ram is removed.

Booster vaccination: The primary vaccination should be repeated 771 days after the initial vaccination.

To facilitate injection the vaccine should be removed from the refrigerator on the morning of use and kept at room temperature. Unused vaccine must not be returned to the refrigerator. Shake the bottle well before withdrawing doses. Syringes and needles should be sterilised before use and the injection made through an area of clean, dry skin using aseptic techniques.

CONTRA-INDICATIONS, WARNINGS ETC. Do not administer to unhealthy animals. Transient pyrexia and injection site inflammatory reactions may occur. The pyrexia is not associated with any change in appetite or general demeanour. The injection site reaction, which may be palpable as a nodule of approximately 30mm diameter, will normally resolve within 5 weeks. As with all vaccines, occasional hypersensitivity reactions may occur. In such cases appropriate treatment should be given, eg. an antihistamine or corticosteroid.

Some animals in any population may not respond to vaccination as a result of immunosuppression or for other reasons.

STORE ALL MEDICINES OUT OF REACH AND SIGHT OF CHILDREN. FOR ANIMAL TREATMENT ONLY. Mydiavac® may be administered simultaneously in a vaccination programme with a commercial Toxoplasma gondeii vaccine containing live tachyzoites of the S48 strain. Concomitant administration of Mydiavac® and such a commercial Toxoplasma gondeii vaccine does not significantly affect the serological effect to either vaccine or cause any ill effect provided different sites of injection, different syringes and needles are used. Mydiavac® must not be administered concomitantly with live Toxoplasma gondeii vaccines to pregnant animals. No other information is available on concomitant use.

OPERATOR WARNING. To the user: This product contains a mineral oil-based compound. Accidental/self injection may result in severe pain and swelling, particularly if injected into a joint or finger, and in rare cases could result in the loss of the affected finger or thumb if prompt medical attention is not given. Ensure that the method of restraint, handling and administration eg. by the use of guarded needles, minimises the risk of accidental self injection. If you are accidentally injected with the product, seek prompt medical advice even if only a very small amount is injected, and take the package insert with you. If pain persists for more than 12 hours after medical examination, seek medical advice again.

To the Physician: This product contains mineral oil. Even if very tiny amounts have been injected, accidental injection with this oil-based product can cause intense swelling which may, for example, result in ischaemic necrosis and the loss of a digit.

Expert, PROMPT, surgical attention is required and may necessitate early incision and irrigation of the injected area, especially where there is involvement of finger pulp or tendon.

This product contains mineral oil. Even if very tiny amounts have been injected, accidental injection with this oil-based product can cause intense swelling which may, for example, result in ischaemic necrosis and the loss of a digit.

Expert, PROMPT, surgical attention is required and may necessitate early incision and irrigation of the injected area, especially where there is involvement of finger pulp or tendon.

WITHDRAWAL PERIOD. Zero days. However, if a live Toxoplasma gondeii vaccine has been administered concomitantly, the withdrawal period applicable to that vaccine should be observed.

PHARMACEUTICAL PRECAUTIONS. Store between +2°C and +8°C. Do not freeze. Shake the container well before withdrawing a dose of vaccine. To facilitate injection the vaccine should be removed from the refrigerator on the morning of use and kept at room temperature. Unused vaccine must not be returned to the refrigerator. Once broached the contents of the vial must be used within, or discarded by the end of, that working day.

LEGAL CATEGORY. POM-V. To be supplied only on veterinary prescription.

PACKAGE QUANTITIES. 20ml glass vials and 100ml collapsible polyethylene packs.

FURTHER INFORMATION. Abortion in sheep may have other causes. When the diagnosis is in doubt or when sheep vaccinated with Mydiavac® abort, it is strongly recommended that veterinary advice is sought.

USE MEDICINES RESPONSIBLY. The safety and efficacy of Mydiavac® administered to pregnant sheep has been studied in challenge experiments. These studies have demonstrated the safety of this practice. A reduction in abortion and infection was evident in pregnant ewes challenged following vaccination and in pregnant ewes vaccinated after challenge. On the basis of this evidence, Mydiavac® could be used as an aid in the control of Chlamydophila abortus infection, even in the face of an outbreak. Unused product and/or containers should be disposed of in accordance with advice from a local waste disposal authority.

Vm 43684/4000

MANUFACTURED & DISTRIBUTED BY: Benchmark Vaccines Ltd, Braintree, CM7 2YW

MARKETING AUTHORISATION HOLDER. Benchmark Animal Health Ltd. Benchmark House, 8 Smithy Wood Drive, Sheffield, S35 1QN. Tel: 0845 009 3342. Made by Benchmark Animal Health Ltd in Braintree under licence from Novartis Animal Vaccines Ltd. Mydiavac® is the registered trade mark of Vericore Ltd.

Mydiavac - Proven enzootic abortion protection,
flexible and practical administration


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